Seattle showed that you can throttle Kaepernick and the 49ers by bringing pressure up front, but the Colts just don't have that physicality and I expect Kaepernick to return to form. That should open things up for the run game (even though San Francisco have struggled to establish that aspect of their offense) and keep Indianapolis off-balance, especially with the injuries the Colts are carrying on D.
The Trent Richardson acquisition has set hearts a-fluttering in Indy, and he'll doubtless get the rock tonight, but the 49ers, even after Lynch's performance last week, remain an awkward to team to run on and he only arrived on Wednesday.
Luck looked a little off his game last week and is behind a mediocre offensive line and they lost guard Donald Thomas during the week. The 49ers can be beaten deep, but Luck will need room to operate and it's likely to be in short supply.
I don't like to lay double digits in football, but I think with the matchups and a coach like Harbaugh (he'll look foward to showing his former college QB who's the boss) coming off a loss, San Francisco are clear favourites.
Pick: San Francisco 49ers -10 @ 2.0
Pick: 1st TD Frank Gore @ 8.5
Pick: Anytime TD Colin Kaepernick @ 2.4
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